Student Internship in Protein Science (from July 2019, 6 Months) in Basel

The Lead Discovery Department in Small Molecule Research is part of Therapeutic Modalities (TMo) within Roche Pharma Research and Early Development (pRED). We deliver leading edge science to drive the success of Roche’s early pipeline discovery research activities through a strong expertise in high throughput or focused screening platforms, DNA encoded library technology, protein science & enzymology/biophysics, cell-based assays and screening and biostructure determination. We are accountable for the provision of high quality chemistry starting points for Small Molecule projects and generating molecular and mechanistic insights that are critical for the advancement of discovery projects.

During the internship you will

• Actively contribute in an early-phase drug discovery project by performing membrane protein purifications
• Apply and optimize tools (Nanodiscs, Sybodies) for protein stabilization and x-ray structure determination
• Learn a broad spectrum of methods to characterize proteins in terms of stability, enzymatic activity and interaction with small-molecule ligands
• Get hands-on experience on laboratory automation and robotics
• Plan experiments and present your findings in group seminars
   

Who you are

You’re someone who wants to influence your own development. You’re looking for a company where you have the opportunity to pursue your interests across functions and geographies. We are looking for an enthusiastic and proactive master student in the area of biochemistry or related fields with a good knowledge in protein purification and characterization. You are highly motivated, interested in a multidisciplinary and multinational environment and you have already gained some laboratory experience.

Moreover you are/have:

• Experience with protein purification and analytical methods beyond SDS-PAGE, ideally also with protein structure determination
• Good knowledge in molecular biology (cloning, construct design, expression strategies)
• Excellent organizational skills and a pro-active knowledge sharing
• Self-motivated and focused, able to multi-task, and meet timelines efficiently and productively
• Fluent in English and/or German

The Internship can start between July and August 2019 - please clearly indicate your preferred starting date on your motivation letter.

To be considered, all applications always need to include a CV, motivation letter and certificate of enrollment in one merged PDF document.

Due to regulations non-EU/EFTA citizens must provide a certificate from the university stating that an internship is mandatory (“recommended” is not sufficient) as part of the application documents.

If you still have questions, then please check our FAQs and videos on careers.roche.ch/faq