Job Description More than 1’000 drugs have been associated with idiosyncratic heptotoxicity. Drug-Induced Liver Injury (DILI) therefore represents a major challenge for industry and regulatory authorities. Unfortunately, a drug’s idiosyncratic hepatotoxicity potential can only be recognized post-marketing, and DILI has therefore also been the most frequent single reason for withdrawing drugs from the market.
Your responsibilities include, but are not limited to:
• In vitro evaluation of reversible and irreversible inhibition potential on metabolizing enzymes and drug transporters • Determination of various hepatotoxicity readouts (e.g. ROS, mitochondrial tox, cell death, GSH adduct formation, GSH/GSSH ratio) • Further evaluation and development of the so-called Extended Clearance Model (ECM) in order to illustrate its ability to accurately anticipate and predict hepatocellular cell stress elicit by drug candidates • Establishment of correlations between process inhibition, intracellular bile acid accumulation and potential hepatotoxicity readouts (e.g. apoptosis, cell death, canalicular efflux pump upregulation) • Development of an integral DILI assessment decision tree (e.g. by introducing discovery of Adverse Outcome Pathways (AOPs))
Minimum requirementsWhat you’ll bring to the role: • Degree in organic/analytical/biochemistry or applied data science (MSc) • Willingness to engage in a University PhD program • High level of familiarity with data mining and big data concepts • Good attention to detail, an analytical investigative and questioning nature, with an innovative solution-oriented approach • A sharp and objective intellect, experienced in balancing big picture thinking with an investigative nature, drilling into detail as appropriate • Well-developed interpersonal skills with good presence; experienced presenter and communicator • A self-starter and decision taker; open, confident and persuasive, succeeding through influence • Good planning, prioritization, problem solving and organizational skills • Resilient, energetic and enthusiastic; responding constructively to challenging new ideas and inputs • Team player, ability to be flexible and adapt to a changing environment • Good knowledge of English language • Good IT skills particularly Word, Excel and PowerPoint
Why consider Novartis? 750 million. That’s how many lives our products touch. And while we’re proud of that fact, in this world of digital and technological transformation, we must also ask ourselves this: how can we continue to improve and extend even more people’s lives?
We believe the answers are found when curious, courageous and collaborative people like you are brought together in an inspiring environment. Where you’re given opportunities to explore the power of digital and data. Where you’re empowered to risk failure by taking smart risks, and where you’re surrounded by people who share your determination to tackle the world’s toughest medical challenges.
We are Novartis. Join us and help us reimagine medicine.
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