Postdoctoral Fellow - primary blood cell genome editing and engineering in Zürich

100%, Zurich, temporary

The at ETH Zurich develops and uses next-generation genome editing and regulation technologies. We work on both fundamental biological discovery and potential therapies for human genetic diseases. Our focus is the mechanisms by which cells repair their DNA, maintain and differentiate hematopoietic stem cells, and regulate organelle abundance during differentiation and in the face of stress. Through technology development, mechanistic cellular biochemistry, and translational projects, we are working to unravel complex cellular phenotypes to further biological understanding and improve human health. We are a collaborative and multidisciplinary lab, looking for colleagues who like to discuss their science and share their expertise with others.

We are looking for a full-time postdoc (100%) interested in genome editing and engineering of primary blood cells. These approaches will be used to ask fundamental questions about cell biology and to design new therapeutic strategies. Hematopoietic stem cells are one focus of the lab, but other primary blood cell types are also of interest. The candidate will work on new methods to track cell identity and state via sequence-based barcoding, modify endogenous sequences to cure genetic disorders, and link genotype with phenotype via single cell technologies. You will have access to state-of-the-art facilities, outstanding colleagues, and freedom to develop your own independent research focus as you transition to an independent career.

Required Experience

• Ph.D. in molecular and cell biology, genomics, molecular medicine, or a related discipline
• Human cell culture (immortalized or primary cells)
• Next-generation sequencing for functional genomics (e.g. one or more of RNA-seq, ChIP-seq, ATAC-seq, CRISPR libraries, etc)
• At least one peer-reviewed, first-author publication
• Collaborative and curious mindset
• Proficiency in speaking and writing English

Preferred Experience

• Single-cell sequencing technologies
• BSL2 viral work (lentivirus and/or adenoassociated virus)
• Mouse work
• Some familiarity with bioinformatics analysis (e.g. pipelines for *-seq)

Women and underrepresented minorities are particularly encouraged to apply.

ETH Zurich is one of the world’s leading universities specialising in science and technology. We are renowned for our excellent education, cutting-edge fundamental research and direct transfer of new knowledge into society. Over 30,000 people from more than 120 countries find our university to be a place that promotes independent thinking and an environment that inspires excellence. Located in the heart of Europe, yet forging connections all over the world, we work together to develop solutions for the global challenges of today and tomorrow.