Job Description Post-doc for development of an in-vitro T-cell activation assay for quality control
We are looking for an experienced Postdoc in Cell & Gene Therapy Analytics drug product development for Cell- and Gene Therapy-based drug products, with special focus on Cell therapy. As a member of the Cell and Viral Vector Process Development Unit, Technical Development NBEs, you will play a key role in the development of cell and gene therapy products. You will be responsible for the analysis and characterization of cell and gene therapy products in clinical development.
Your main responsibility will be the independent development of an assay that mimics a T-cell response in vitro. This will require extensive literature research, evaluation of multiple assay formats and collaboration with internal experts as well as with external companies. Ultimately, you will be involved in the transfer of the fully developed assay to a quality control group to implement the method in a GMP environment. Major Accountabilities: - Development of a T-cell activation assay, including extensive literature research and evaluation of different formats. - Interaction with collaborators from research (early phase of assay development), as well as the quality control (late phase of assay development). - Proactive communication of key issues and any other critical topics in a timely manner - Contribution to evaluation of new scientific technologies/equipment as required.
Minimum requirements- Strong background in immunology/Cell biology at PhD level - Knowledge of relevant laboratory and/or technical tools. - In depth FACS experience is highly desirable. - Scientific knowledge of mammalian and primary cell culture - Good communication skills in English. Good presentation skills and scientific/technical writing skills. - Hands-on laboratory work experience, preferably in a BL-2 environment - Experience in experimental planning, data evaluation, presentation and report writing Duration: 18 months, starting with literature research over early evaluation of different formats through full assay development up to hand-over to a QC laboratory
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