PhD Position in Hypoxia-mediated Pexophagy and the Role of Peroxisomes in Cancer in Zürich

100%, Zurich, fixed-term

From January 2021, the Molecular Oncology Lab, headed by Prof. Nicola Aceto, is located at the Institute of Molecular Health Sciences of the Department of Biology (D-BIOL) within the ETH Hönggerberg campus, the Life Science Campus of ETH Zurich, and comprise a team of dedicated scientists and collaborators across different clinics and pharmaceutical companies.

of PD Dr. Werner Kovacs combines a wide variety of disciplines to answer outstanding questions in cancer research, with a particular emphasis on the molecular mechanisms of HIF-2a-mediated pexophagy and the role of peroxisomes in tumorigenesis and metastasis. Investigations will range from the study of the mechanisms of HIF-2a-mediated pexophagy, screens to identify regulators of HIF-2a-mediated pexophagy and therapeutic candidates for clear cell renal cell carcinoma and hepatocellular carcinoma, and the role of altered peroxisome abundance in metabolic reprogramming and tumor growth. These studies will involve the application of state-of-the art genomics, biochemical/cell/ molecular biological and screening technologies and the use of mouse models of cancer. The position offers excellent scientific opportunities in a highly stimulating and interdisciplinary environment involving close interactions between scientists from different disciplines.

We seek a highly motivated PhD student interested in studying the molecular mechanisms of HIF-2a-mediated pexophagy and the role of peroxisomes in tumorigenesis.

Our ideal candidate is:

• A highly motivated applicant with a MSc or MD degree and a strong background in biochemistry, cell and molecular biology, genetics, cancer research and pathophysiology. 
• Familiar with cell culture and molecular biology and willing to work with mice
• Excited to work in a highly-collaborative environment that includes molecular biologists, clinicians, and computational biologists
• Capable of independent thinking, ambitious, focused on discovery and dedicated to perform research of the highest quality 
• A team player with excellent communication and writing skills (English)

ETH Zurich is one of the world’s leading universities specialising in science and technology. We are renowned for our excellent education, cutting-edge fundamental research and direct transfer of new knowledge into society. Over 30,000 people from more than 120 countries find our university to be a place that promotes independent thinking and an environment that inspires excellence. Located in the heart of Europe, yet forging connections all over the world, we work together to develop solutions for the global challenges of today and tomorrow.