Studierende finden an der ETH Zürich ein Umfeld, das eigenständiges Denken fördert, Forschende ein Klima, das zu Spitzenleistungen inspiriert.
Why do cells control their size and how is it possible that different cells in our body vary 1000 fold in size and can still function? We are looking for a new member to join our team to study these fundamental questions.
From bacteria to eukaryotes all cells of a specific type have a characteristic size. Size homeostasis is therefore a universal feature of cells. Deviations from normal size coincide with altered cell function during pathological processes, such as cell senescence or cell transformation, suggesting that having a defined size is critical for optimal function. This optimal size can however vary: Unicellular organisms adjust their size to environmental conditions and within the same multicellular organism different cell types can have vastly different sizes. Cell size is therefore tightly regulated but can vary substantially. Our lab is interested in understanding why it is important for cells to have a specific size and how changes in cell size contribute to altered function during cell senescence and differentiation. For this purpose, we use a combination of genetics, live cell microscopy and quantitative transcriptomics and proteomics approaches in budding yeast and mammalian systems.
The advertised project aims at understanding how naturally occurring changes in cell size contribute to altered cell function in multicellular organisms. To this end, you will establish an in vitro model system to manipulate cell size changes during differentiation and describe how this affects key parameters such as overall proteome composition, nuclear function and differentiation.
We are looking for a curious, pro-active mind who is motivated to study fundamental biological questions. You should bring:
ETH Zurich is one of the world’s leading universities specialising in science and technology. We offer the possibility to work with an international team of young scientists in this vibrant research environment, an ideal place excell and launch the next step in your career.
We look forward to receiving your online application with the following documents:
Applications will be considered on a rolling basis until a suitable candidate is found. For questions regarding the position please contact .
28-02-2024
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