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Roche Postdoctoral Fellowship in Computational Modeling of Amyloid Related Imaging Abnormalities (2 years) in Basel

Roche ist ein Arbeitgeber, der die Chancengleichheit fördert.

Jobbeschreibung

At Roche, 80,000 people across 150 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity, and on seeing each other’s differences as an advantage. To innovate healthcare, Roche has ambitious plans to keep learning and growing – and is seeking people who have the same goals for themselves.

The headquarters in Basel is one of Roche’s largest sites, over 8,000 people from approximately 80 countries work at Roche Basel. Favored by its geographic location in the heart of Europe, the Basel area is one of the most dynamic economic regions in Switzerland – a great place to live and work.

The Roche Postdoctoral Fellowship (RPF) program is aimed at supporting excellent young scientists focusing on collaborative R&D projects between Roche and international academic institutions. Both internal Roche and academic experts will mentor you, and you will be based mainly at the main Roche campus in Basel, Switzerland.

Roche is a global leader in developing therapeutic antibodies for the treatment of Alzheimer’s disease. This long term effort will now be supported by the Pharmaceutical Sciences department with a two-year fellowship program to develop a state of the art computational model of amyloid related imaging abnormalities (ARIA), which are often associated with anti-amyloid therapies. The computational model of ARIA will provide an in-silico laboratory for investigating the pathophysiological mechanisms responsible for ARIA and for evaluating novel approaches to ameliorate it.

This post-doctoral position will entail the development and application of a computational model of ARIA based on experimental data from clinical and pre-clinical studies, and current mechanistic hypotheses formulated in collaboration with leading academic researchers.

The project will involve:

  • a data collection phase
  • development of a conceptual model of ARIA
  • translation into a computational model of ARIA
  • calibration, validation and in-silico simulations of ARIA

The computational model of ARIA will support and inform the development of novel dosing regimens that minimize ARIA risk, improve patient convenience and/ or enhance the efficacy and durability of anti-amyloid therapy. The resulting model and simulations will be published in high-impact journals and presented at internal and external meetings.


You’re someone who wants to influence your own development. You’re looking for a company where you have the opportunity to pursue your interests across functions and geographies. Where a job title is not considered the final definition of who you are, but the starting point.

We are seeking a highly motivated and talented Postdoc to join our international team in an outstanding and competitive scientific environment. The person we are looking for possesses excellent communication skills, enjoys working in multidisciplinary teams and is fluent in English. If you have recently completed your Ph.D. (obtained within the last 4 years) in mathematics, computational biology or a related modeling discipline, your profile might be interesting for us.

If you bring as well the following set of skills and expertise we are looking forward to receiving your application:

  • a fluent English speaker
  • possess excellent scientific writing and presentation skills
  • enjoy working in interdisciplinary environments, collaborating with experimental neuroscientists, pharmacologists and computational disease modelers
  • have relevant experience developing computational models in neuroscience and neurodegeneration, preferably related to CSF dynamics, solute clearance and the pathophysiology of Alzheimer’s disease
  • fluent programming abilities in Python, C++, Fortran, MATLAB and Berkeley Madonna
  • a strong analytical thinker and problem solver, able to communicate mathematical concepts in conceptual terms to diverse audiences, self-directed and also comfortable receiving the input of others

Please include a detailed CV with a publication list and contact information for at least two references, and a cover letter with your expected date of availability.

For questions please call the Recruiting Team Switzerland: +41616822550

At Roche, 94,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.

Roche is an equal opportunity employer.

Veröffentlicht am

29-02-2024

Extra Informationen

Status
Inaktiv
Standort
Basel
Jobart
Praktikum
Tätigkeitsbereich
Chemie / Pharmazie
Führerschein erforderlich?
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Auto erforderlich?
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