The Novartis Institutes for BioMedical Research (NIBR) is the innovation engine of Novartis. We collaborate across scientific and organizational boundaries, with a focus on powerful new technologies that have the potential to help produce therapeutic breakthroughs for patients.
A postdoctoral position is available in the laboratory of Tobias Schmelzle, PhD with the co-supervision of Giorgio G. Galli, PhD, within the Oncology department of the Novartis Institutes for BioMedical Research (NIBR) in Basel, Switzerland.
Our laboratories are interested in characterizing the role of the Hippo signaling pathway in cancer (Michaloglou et al., 2013; Galli et al., 2015; Mesrouze at al., 2017). While this pathway is a key regulator of organ size and embryonic development, the past decade highlighted its function in driving tumorigenesis and drug resistance mediated by the aberrant activation of the YAP/TAZ-TEAD transcriptional complexes. Despite several publications described upstream regulators and downstream targets of the pathway, a detailed mechanistic understanding of the pathway output in disease-relevant setting is lacking. To this end, we employ a variety of experimental approaches such as large-scale functional genomic screens (McDonald et al., 2017), CRISPR-Cas9 genome editing, epi-/genomic profiling and mass-spectrometry based proteomics. The overall goal will be to identify novel vulnerabilities or therapeutic opportunities in cancers driven by aberrant Hippo pathway activity.
We are looking for a highly motivated and hard working candidate with a good level of independence and creative thinking. The successful candidate will join a vibrant scientific community and collaborate with other postdoctoral fellows mentored by a range of scientists across disciplines and platforms, including chemistry, structural biology, molecular biology, functional genomics, neurophysiology and translational medicine. Postdoctoral scholars at NIBR have a unique opportunity to conduct innovative, interdisciplinary research and are expected to publish their results in leading journals. The postdoctoral term is up to 4 years.
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PhD in life sciences with demonstrated productivity as assessed by publications and a strong interest in signal transduction and transcriptional regulation English - Experience with functional genomics screens and epi-/genomic profiling is an advantage - Experience in handling and interpreting genomic data is essential
Please submit your cover letter and CV, including the contact information (name, institution, phone number, and e-mail address) of 3 references.
For more information about our postdoctoral program, please visit https://www.novartis.com/our-science/postdoc-program
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