Postdoctoral scholar - Immunology and Dermatology NIBR BASEL
The Novartis Institutes for BioMedical Research (NIBR) is the innovation engine of Novartis. We collaborate across scientific and organizational boundaries, with a focus on powerful new technologies that have the potential to help produce therapeutic breakthroughs for patients.
The translational research group in the Autoimmunity, Transplantation and Inflammation Disease Area utilizes state-of-the-art technology and computational biology to improve our understanding of underlying, causative pathways in autoimmune and inflammatory diseases. We are particularly interested in dissecting the role of CD40-CD154 interactions in disease, and have generated and characterized a pathway blocking, non-depleting anti-CD40 antibody (CFZ533) currently in clinical development for allograft transplantation and autoimmune disease.
We are looking to recruit a postdoctoral fellow to systematically examine the relationship between CD40 receptor internalization and multiple downstream signaling pathways in various CD40-expressing cell types, including following-up on novel hits generated from an in-house, genome-wide CRISPR screen. We are equipped with state-of-the-art flow cytometry, imaging, biochemical and molecular technologies as well as expertise in CRISPR, immunology and translational research, as well as a variety of tools to interrogate CD40 expression, and pathway activation.
The successful candidate should have experience in the cellular and biochemical regulation of endocytosis and endosomal trafficking, as well as knowledge of immunology. Expertise in imaging and cutting-edge microscopy will be highly regarded. The postdoctoral fellow will join a vibrant scientific community and collaborate with other postdoctoral fellows mentored by a range of scientists across disciplines and platforms, including chemistry, structural biology, molecular biology, functional genomics, neurophysiology, computational biology and translational medicine. Postdoctoral scholars at NIBR have a unique opportunity to conduct innovative, interdisciplinary research and are expected to publish their results in leading journals. The postdoctoral term is up to 4 years.
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Qualifications: - PhD in cell biology with a focus on endocytosis and endosomal trafficking (PhD students in the last year of their thesis work, are eligible to apply) - Knowledge of immunology, and/or TNF-receptor biology a plus - Expertise in cellular imaging highly regarded - Strong publication record - Excellent analytical, communication and organizational skills - Candidates must be able to work independently as well as with interdisciplinary teams
Please submit your cover letter and CV, including the contact information (name, institution, phone number, and e-mail address) of 3 references.
For more information about our postdoctoral program, please visit https://www.novartis.com/our-science/postdoc-program
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