Postdoctoral position in Structural Bioinformatics in Zürich

100%, temporary

A post-doctoral position is available in the group of Prof. Picotti at the Institute of Molecular Systems Biology. The successful candidate will develop approaches to analyze protein structural transitions in situ and on a proteome-wide scale, visualize these transitions, and use data for integrative structural biology.

The Picotti lab exploits a novel, high-throughput approach relying on mass spectrometry to identify protein structural rearrangements on a large scale and directly from biological samples. These data sets are continuously generated in the lab for multiple systems and organisms, including human, under a range of conditions. You will develop approaches for analyzing this dynamic data and derive novel biological insight. Furthermore, you will work on the visualization of this data and its dissemination. You will probe, in a collaborative project with the laboratory of Andrej Sali (UCSD), how dynamic structural data can be used in integrative structural biology efforts.

You will be part of a vibrant and collegial team of scientists working at the cutting-edge of structural proteomics. You will be trained to handle data from cutting-edge targeted and unbiased proteomic technologies based on mass spectrometry, including selected reaction monitoring, data-independent acquisition and shotgun analysis. You will apply bioinformatics approaches to structural systems biology analysis. You will have the opportunity to be involved in cross-disciplinary collaborations and to access state-of the-art facilities.

Applicants should have a solid background in structural bioinformatics, a strong publication record as primary author, a good command of written and spoken English, as well as excellent verbal and written communication skills. Familiarity with large-scale data sets and with proteomic data is preferable but not required. Importantly, you must be able to work independently but also as a part of a team. An interest in technology development as well as systems biology concepts and approaches is highly recommended.

ETH Zurich is one of the world’s leading universities specialising in science and technology. We are renowned for our excellent education, cutting-edge fundamental research and direct transfer of new knowledge into society. Over 30,000 people from more than 120 countries find our university to be a place that promotes independent thinking and an environment that inspires excellence. Located in the heart of Europe, yet forging connections all over the world, we work together to develop solutions for the global challenges of today and tomorrow.