Postdoc - development and applications of direct in vivo CRISPR screening in Zürich

100%, Basel, temporary

The Laboratory for Biological Engineering (Prof. Randall J Platt) of the Department of Biosystems Science and Engineering in Basel, Switzerland develops genome engineering technologies and applies them to a range of fundamental and disease-focused areas (). To advance these efforts, the Platt group is seeking a full-time Postdoctoral Associate to develop and apply in vivo functional genomic methods.

We are looking for a highly motivated and collaborative researcher to be integrated in a multidisciplinary team of scientists. The candidate will both develop novel molecular methods as well as apply them to ask fundamental questions about brain development and function in the context of health and disease. The candidate will be passionate about science, technology, collaboration, and communication.

The position is located in the Department of Biosystems Science and Engineering (D-BSSE) of the ETH Zurich located in Basel, Switzerland. The D-BSSE () is a highly interdisciplinary department – specializing in systems and synthetic biology, bioinformatics and data science, and engineering sciences related to microfluidics and microfabrication. The D-BSSE is centrally located within a biomedical research hub with close links to top academic institutions (e.g., Friedrich Miescher Institute (FMI), Biozentrum and University of Basel) as well as major biotechnology and pharmaceutical companies (e.g., Novartis, Roche, Bayer, and Lonza). The ETH Zurich () is a global leader in science and technology and consistently ranks as one of the top universities in the world. Basel, Switzerland is an international city on the border with France and Germany – nested between the Swiss alps, black forest, and cheese and wine country. The city provides easy access to arts and culture, nature and adventure, and short commutes via train/plain/automobile to anywhere in Europe.

The ideal candidate should have a Ph.D. or equivalent in Biology, Neurobiology, Molecular Biotechnology, Molecular Medicine, or a related field. The candidate must have extensive experience working with a range of methods for the in vivo interrogation of mouse models, including virus production and delivery (with at least AAV  and LV), survival surgeries, histological techniques and imaging (quantification), primary cell isolation and culture, and preparation of deep sequencing libraries for functional genomics experiments (e.g. (sc)RNA-seq, ATAC-seq, ChIP-seq, lineage barcoding). Knowledge in bioinformatics, statistics, and programming are a major plus. The candidate must have a strong track record and interest in collaboration with multi-disciplinary scientists. Other required qualifications are the ability to communicate effectively in a highly interdisciplinary and international environment, which includes a mastery of oral and written English as well as scientific illustration using Adobe Illustrator or equivalent.

ETH Zurich is one of the world’s leading universities specialising in science and technology. We are renowned for our excellent education, cutting-edge fundamental research and direct transfer of new knowledge into society. Over 30,000 people from more than 120 countries find our university to be a place that promotes independent thinking and an environment that inspires excellence. Located in the heart of Europe, yet forging connections all over the world, we work together to develop solutions for the global challenges of today and tomorrow.