The Patriarchi lab is searching for highly motivated, hard-working and talented PhD students.
In the project, the student will learn and use novel protein engineering and high-throughput screening techniques for the development of GPCR-based genetically encoded fluorescent sensors for neuromodulators [see: Patriarchi et al Science (2018) 360 (6396); Patriarchi et al Nat Protoc (2019) 14:3471-3505; Patriarchi et al Nat Methods (2020)]. The student will then have the opportunity to validate these new tools in brain slices and living animals, with a combination of slice electrophysiology/optogenetics, as well as in vivo imaging techniques (single and multi-fiber photometry) and will then use them to investigate important neuromodulatory functions in the mouse central nervous system.
The candidate should have a in a relevant discipline biotechnology, molecular biology, neuroscience, etc.), a very creative approach to science, and a track record of accomplishments (evidenced by co-author publications in the respective field). Furthermore, candidates are expected to be able to work independently and in teams, and have excellent English written and oral communication skills. Prior experience with protein engineering and/or optogenetic techniques will be considered an asset.
The working language is English, knowledge of German is not required. If you are interested, please send your application package to . Please include the following information: a 1-page cover letter outlining your main past contributions, research activities and interests; your curriculum vitae; your list of publications; contact information for 3 referees.
The Patriarchi lab is embedded into the highly vibrant Zurich Neuroscience Center community (ZNZ:
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