PhD Position in Osteoarthritis Research in Zürich

100%, Zurich, temporary

The Tissue Engineering + Biofabrication laboratory in the Departement of Health Sciences & Technology is searching for a PhD student to study the role of inflammation and diet on osteoarthritis.

In a recent white paper by the Osteoarthritis Research Society International (OARSI), osteoarthritis (OA) was estimated to affect 5% of the global population, and it is the 10th highest cause of Years Lived with Disability. The strong association of OA with co-morbidities greatly increases the socioeconomic cost of the disease. Unfortunately, there is no cure or effective therapy to slow the progression of the disease. The past decade has brought a realization that OA is not just a wear-and-tear disease but also has a strong inflammatory component, which needs to be addressing in development treatment stategies. In addition, the causal links between high-fat diet, joint inflammation and disease progression need to be established.

This innovative project investigates the role of inflammatory agents in the initiation and potentiation of osteoarthritis (OA). Firstly, mass spectrometry is used to identify the bacterial components which are upregulated in synovial fluid of OA patients. We then test these species for their pro-inflammatory properties in vitro and in rodent models of OA. Progression of OA will be assessed using quantitative contrast-enhanced micro computer tomography. 

We are looking for a highly motivated and creative person who enjoys working in a multidisciplinary team on a project with high relevance to human health. You have a flair for quantitative, technical experimentation and excellent written and spoken communication skills. You are able to manage a project with several collaborators and have a Master degree in biology, pharmacy, biomedical engineering, animal science or a related field. Participation in animal studies is an essential component of this project. The start of the position is Spring 2021. 

ETH Zurich is one of the world’s leading universities specialising in science and technology. We are renowned for our excellent education, cutting-edge fundamental research and direct transfer of new knowledge into society. Over 30,000 people from more than 120 countries find our university to be a place that promotes independent thinking and an environment that inspires excellence. Located in the heart of Europe, yet forging connections all over the world, we work together to develop solutions for the global challenges of today and tomorrow.