Postdoc in TRD-ARD in Basel

Die Nocartis AG hat seinen Sitz in Basel und ist eines der grössten Pharmaunternehmen der Welt!


Postdoc in TRD-ARD
Job Description 9.4 billion spend on Research and Development. That commitment resulted in 24 major regulatory approvals in 2019 in the US, EU, Japan and China.
As part of Technical Research and Development, you can make a difference to millions of patients around the world by continuous improvement of drug development and upcoming exciting launch products.

Ultrasound Extinction Spectroscopy (USE) is an established particle size analysis technique for on- and in-line monitoring in suspension and emulsion process technology. USE is applicable to pharmaceutical suspension process development and process monitoring with Active Pharmaceutical Ingredients (API) for oral, ophthalmic and parenteral formulations and API crystallization. However, it has certain limitations regarding process conditions, material properties of the disperse system and kinetics during the process.
This scientific project aims to:
• Investigate sensitivity, accuracy, repeatability and robustness of the USE analysis technique under process conditions.
• Evaluate and establish a suitable and robust range with respect to critical process parameters and material properties for excipients and API particles in the micron and sub-micron range.
State of the art crystallization, rotor-stator milling, wet media milling technology and complementary analytical techniques will be applied.

Timing: Expected start date September 2021
Duration: 2 – 3 years

Your responsibilities:
• Design, plan, perform, interpret and report results of scientific experiments for the characterization of material properties and process conditions and the evaluation of the functional relation to drug substance / drug product manufacturing and quality.
• Utilize special analytical and process tools / equipment and / or specialized facilities.
• Drive the experimental characterization of particulate and bulk drug substances / drug product properties by available and / or new analytical technologies / methodologies.
• Deepen the understanding of drug substance / drug product manufacturing and related drug product down-streaming processes.
• Evaluate and apply when appropriate modeling and simulation tools to characterize particulate and bulk properties, process conditions and their function / behavior in relation to drug substance / drug product manufacturing.
• Interact / collaborate with other groups / functions to drive own objectives and to facilitate transfer of knowledge, analytical methods and established methodologies.
Minimum requirements • Education: Advanced degree in a scientific or relevant discipline, e.g. applied physics, particle technology, chemistry, pharmacy, chemical or process engineering, (Ph.D. or equivalent).
• Languages: Good knowledge of English (oral and written). Desirable knowledge of site language.
• Experience/Professional requirement
• Successfully demonstrated several years (minimum of 3 years) of directly related experience as scientist, Ph.D. or equivalent.
• Broad scientific or technical knowledge in a specific area.
• Advanced knowledge on the operation of experimental laboratory and technical tools.
• Advanced knowledge on the operation of analytical tools, proven analytical mindset and skills.
• Good knowledge on modeling and simulation tools.
• Skilled in literature searches, review and consolidation of relevant scientific information.
• Good presentation skills and scientific/technical writing skills.
• Good communication skills, basic coaching skills.

Why consider Novartis?
799 million. That’s how many lives our products touched. And while we’re proud of that, in this world of digital and technological transformation, we must also ask ourselves this: how can we continue to improve and extend even more people’s lives?

We believe the answers are found when curious, courageous and collaborative people like you are empowered to ask new questions, make bolder decisions and take smarter risks.

We are Novartis. Join us and help reimagine medicine.
Global Drug Development
Novartis Pharma AG
Interns/Students on Novartis Payroll
Full Time

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Medizin / Gesundheitswesen, Management
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