Postdoctoral position in metabolomics in Zürich

100%, Zurich, fixed-term

The Institute of Molecular Systems Biology at ETH Zurich is inviting applications for a Postdoctoral position in the laboratory of .

The group of Dr Zamboni researches the function and regulation of metabolism. In particular, the group is attracted by (i) systems in which metabolism or metabolites drive phenotypic differentiation, (ii) problems of biomedical relevance, and (iii) cases that are especially complex or technically challenging. To tackle such problems, the group adopts cutting-edge mass spectrometry (i.e. metabolomics, lipidomics, and quantitative 13C metabolic flux analysis) and computational methods.

A key focus of the group is on the development of high-throughput methods, which allow to rapidly screen large cohorts of, i.e. clinical samples, drug libraries, or mutant collections. By combining high-resolution, untargeted mass spectrometry and newly engineered software pipelines, the group has become very efficient in analyzing studies with tens of thousands of samples without compromising quality and coverage. Beyond internal R&D projects, the group of Dr Zamboni is heavily involved in external collaborations, both national and international. The group is tightly embedded in the Swiss initiatives on personalized health (e.g. ). Here, the main focus is on complementing metabolomics and lipidomics data with tools that assist in data integration and interpretation.

• Contribute to novel developments with original ideas and technical expertise in mass spectrometry.
• Conduct MS analyses on various systems (LC-MS, GC-MS, QQQ, TOFs, and Orbitraps).
• Supervise instrument maintenance. 
• Assist and train non-expert colleagues on planning, executing, and analyzing experiments.
• Communicate with collaborators and vendors.
• Participate in teaching activities.

• Doctoral degree in analytical chemistry or a related field.
• Strong background in mass spectrometry (e.g. metabolomics, lipidomics, or proteomics)
• Excellent technical skills in LC-HRMS (DDA and DIA workflows), with practical experience in the routine maintenance of MS instruments and LC stacks.
• Genuine passion for metabolomics
• Proactive personality and excellent communication skills.

Further, any expertise in cheminformatics, computational mass spectrometry, or programming is of advantage. 

ETH Zurich is one of the world’s leading universities specialising in science and technology. We are renowned for our excellent education, cutting-edge fundamental research and direct transfer of new knowledge into society. Over 30,000 people from more than 120 countries find our university to be a place that promotes independent thinking and an environment that inspires excellence. Located in the heart of Europe, yet forging connections all over the world, we work together to develop solutions for the global challenges of today and tomorrow.