PhD in Modelling Evolutionary Dynamics of Antibiotic Resistance in Zürich

The Evolutionary Epidemiology group at ETH Zurich is recruiting a curious and enthusiastic PhD student to model the evolutionary dynamics of antibiotic resistance in Escherichia coli.

The position is supervised by and funded by an SNF Prima grant. The Evolutionary Epidemiology group is part of the , led by Prof. Sebastian Bonhoeffer. The group is friendly and collaborative, with people from diverse backgrounds working on a range of projects relating to microbial evolution and dynamics.

The position is funded for 4 years. The start date is flexible, ideally around 1.9.2022.

This project aims to improve our understanding of the ecological and evolutionary principles that govern the spread of antibiotic resistance. We are sampling and sequencing E. coli from a cohort of nursery children to generate a unique dataset on strain diversity and dynamics in the human gut.

Your role in the project will be to infer fundamental aspects of E. coli ecology from these data: how strains compete within the gut and how this competition affects transmission from person to person. You will use these insights to develop mathematical models of antibiotic resistance in E. coli to help explain puzzling trends in resistance dynamics.

The position is ideal for someone combining an interest in theory, real-world data and public health. Curiosity and an aptitude for learning are more important than specific background. Essential requirements are:

• Strong analytical and quantitative skills (MSc in a quantitative subject).
• Fluency in at least one programming language (e.g. R, Python, C++, Matlab).
• Excellent written and oral communication skills in English.

• An exciting project working on a unique dataset in a friendly team and a great city.
• A supportive, stimulating and fun work environment with a strong culture of mentorship.
• Excellent resources for further learning and development at one of the world’s leading research universities.
• Plenty of opportunities for collaboration, attending scientific conferences and building your scientific network.

In line with our values, ETH Zurich encourages an inclusive culture. We promote equality of opportunity, value diversity and nurture a working and learning environment in which the rights and dignity of all our staff and students are respected. Visit our to find out how we ensure a fair and open environment that allows everyone to grow and flourish.