Studierende finden an der ETH Zürich ein Umfeld, das eigenständiges Denken fördert, Forschende ein Klima, das zu Spitzenleistungen inspiriert.
The studies how early life experiences and early circuit activity shapes adult brain function and behaviour. We use circuit neuroscience and developmental neuroscience tools to record or manipulate circuits during critical periods of postnatal development or in adulthood during behaviour. We focus on striatal, mesolimbic and hypothalamic circuits to understand how they regulate motivation, reward and feeding behaviour in the basal state, or following developmental manipulations. Ultimately our goal is to increase our understanding of the aetiology and pathophysiology of neuropsychiatric disorders characterized by maladaptive feeding or altered reward behaviour e.g. eating disorders, addiction, depression, schizophrenia, etc. The group started in 2021 and consists of the PI Marie Labouesse, 1 PhD student and 1 MSc student. Our work is funded by a Junior PI 'Ambizione' Grant from the Swiss National Science Foundation (SNSF), a NARSAD Young Investigator Grant from the Brain and Behavior Research Foundation (BBRF) with additional support from the Zurich Neuroscience Center (ZNZ) and others. Our group is hosted by the Translational Nutritional Biology Laboratory (Prof Christian Wolfrum) which focuses on metabolism and molecular biology: . We share lab space, offices and social events with them. We also belong to the Zurich Neuroscience Center (ZNZ: ) with access to top facilities and potential collaborators.
You will lead a project aiming at establishing a new mouse model for neuropsychiatric disorders. Your goal is to perform cell-specific manipulation of dopamine circuits during development and determine the impact on the brain and behavioural function in adulthood. With our guidance, you will need to acquire new methods, be responsible for designing and performing experiments (stereotaxic surgery, behavioural testing, neuropharmacology, brain histology, in vivo fluorescent imaging, write code for analysis, etc.), analyze data and regularly present it, write a yearly report for grant funders and draft figures/manuscripts for publications. According to interest, you may supervise students and collaborate with other lab members and collaborators on other projects.
Required skills and experience:
Bonus but not required skills and experience:
We will support your scientific growth and goals irrespective of career paths (industry, academia, etc.). We provide excellent working conditions, an internationally competitive salary (paid according to ETH standards), and support for attending local workshops and international conferences. The position is funded for 2 years at 100%. If you want to stay >2 years, we can discuss how to co-apply for additional funding. Part-time work contracts (eg 80%) will be considered. The starting date is flexible, ideally by 1 Feb 2023.
We look forward to receiving your online application with the following documents:
Please note that we exclusively accept applications submitted through our online application portal. Applications via email or postal services will not be considered.
Further information about our Group can be found on . Questions regarding the position should be directed to Dr Marie Labouesse, (no applications).
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