Studierende finden an der ETH Zürich ein Umfeld, das eigenständiges Denken fördert, Forschende ein Klima, das zu Spitzenleistungen inspiriert.
The Wieczorek Lab at the Institute of Molecular Biology & Biophysics at ETH Zurich investigates the physical principles underlying the self-assembly of complex intracellular structures from biomolecules. The group uses the microtubule cytoskeleton as a model system. We apply state-of-the-art methods in structural biology, in vitro biochemical reconstitutions, and single molecule biophysics to understand how diverse multi-microtubule assemblies form from a common tubulin “building block”. The results of our work are important for understanding the molecular basis of diseases such as cancer and neurodegeneration, which are often directly linked to defects in microtubule network assembly.
Previously, we solved the structure of the gamma-tubulin ring complex (gamma-TuRC), a huge multiprotein assembly proposed to nucleate and organize microtubules in cells (Wieczorek, Urnavicius et al. Cell (2019)). We are broadly interested in exploring the following open questions:
1) How does the gamma-TuRC regulate microtubule architecture?
2) How do gamma-TuRC co-factors interact with and regulate the various biochemical functions of the complex?
3) How are various microtubule networks properly established and regulated by the gamma-TuRC in conjunction with tubulin and other microtubule-associated proteins?
You will have the opportunity to explore these and other fundamental cell biological questions as the basis of their postdoc project in the group.
The group has access to state-of-the-art electron microscopy instrumentation, including FEI Vitrobots and related grid preparation facilities and three Titan Krios microscopes, all hosted and maintained at ETH Zurich’s imaging facility, ScopeM. Appropriate computational resources are also readily available within the group and through a central computational cluster at ETH Zurich.
This is a fully funded position for a maximum of 4 years with an anticipated start date of January 1st, 2023 (negotiable). Further project details will be discussed during the interview.
We are looking for an enthusiastic and highly-motivated individual to investigate how microtubules self-assemble. You will develop cutting-edge assays for determining structural snapshots of microtubule assembly at near-atomic resolution.
ETH Zurich is a family-friendly employer with excellent working conditions. You can look forward to an exciting working environment, cultural diversity and attractive offers and benefits.
We look forward to receiving your online application with the following documents:
Evaluation of applications will start immediately and will continue until a suitable candidate has been identified. Please note that we exclusively accept applications submitted through our online application portal. Applications via email or postal services will not be considered.
Further information about the Institute of Molecular Biology & Biophysics can be found on .
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