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The Position

PhD internship -  Surface proteome of endothelial cells 

A healthier future. That's what drives us. 

The RiSE program (Roche Internships for Scientific Exchange) is a highly competitive student research program at Roche. It offers the most talented postgraduate PhD and medical degree students the opportunity to be fully integrated into our interdisciplinary and international industry R&D environment. As a RiSE student you will enhance your competencies, gain valuable work experience with us, and eventually become part of a world-wide network of RiSE Alumni.

The Neuroscience and Rare Diseases Discovery and Translational Area (NRD DTA) is developing medicines for a range of serious neurological diseases, including multiple sclerosis, Alzheimer's disease, Parkinson's disease, autism, spinal muscular atrophy, and Huntington's disease.

As RiSE student in the NRD DTA you will join the Neurovascular Distribution Lab in the Neurotechnologies section at the Roche Innovation Center Basel, Switzerland. We are a multidisciplinary team with expertise in neurovascular biology, blood-brain barrier function, disease biology and in vivo models of the central nervous system. 

The opportunity:

• Performing exploratory lab work to investigate the identity of brain endothelial cells and to this end, determining the surface proteome of brain endothelial cells in situ using novel technologies 

• Performing animal work (LTK1 or similar required)

• Optimising brain explant culture conditions for endothelial cell viability

• Applying cutting-edge cell isolation techniques

• Using state of the art techniques to analyse the cell surface proteome of endothelial cells in vitro and ex vivo

• Summarising your work for internal and external meetings and draft a publication

Who You Are

• Enrolled in a PhD or medical degree program at a university and are looking to expand your experience with an industry internship

• A valid LTK1/FELASA B animal licence

• Proficient in neuroscience, vascular biology and/or cell biology and good knowledge of analysis methods for omics datasets

• Extensive experience in biochemical methods including sample preparation for mass spectrometry; experience with organotypic brain slice culture will be beneficial

• Experience with cell isolation, immunostainings and/or fluorescence imaging

The preferred start date of the internship is July 2024 or upon availability.

#RiSE

Who we are

At Roche, more than 100,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we've become one of the world's leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.

Basel is the headquarters of the Roche Group and one of its most important centres of pharmaceutical research. Over 10,700 employees from over 100 countries come together at our Basel/Kaiseraugst site, which is one of Roche`s largest sites.

Besides extensive development and training opportunities, we offer flexible working options, 18 weeks of maternity leave and 10 weeks of gender independent partnership leave. Our employees also benefit from multiple services on site such as child-care facilities, medical services, restaurants and cafeterias, as well as various employee events.

We believe in the power of diversity and inclusion, and strive to identify and create opportunities that enable all people to bring their unique selves to Roche.

Roche is an Equal Opportunity Employer.