Haute Ecole d'Ingénierie

The University of Applied Sciences and Arts Western Switzerland Valais (HES-SO Valais-Wallis) has over 2,800 students. Through research and innovation, it contributes to economic and social development and the creation of jobs. The new Energypolis campus, home to the School of Engineering, EPFL and modern start-ups, is an innovative ecosystem for education and research. Why not come and join us?

The School of Engineering is looking for a :

Automated LC - MS through AI-based and Generative Intelligence Technology

A unique opportunity for a researcher (post-doc) position in an academic/industrial setting.

Position description

The Mass Spectrometry Group at HES-SO Valais-Wallis is seeking a highly motivated and skilled Postdoctoral Researcher with expertise in proteomics, liquid chromatography high-resolution mass spectrometry (LC-HRMS), and biotherapeutic characterisation. The ideal candidate will have hands-on experience with Orbitrap technologies, a strong background in sample preparation, data analysis, and familiarity with bioinformatics tools relevant to proteomics.

You will contribute to advanced research in the utilisation of AI-based and generative intelligence technology in MS-based biotherapeutic profiling and will work closely with a multidisciplinary team, including software engineers and industry partners.

Key responsibilities:

• Perform LC-HRMS-based proteomics workflows, focusing on Orbitrap instruments.
• Design and execute sample preparation protocols.
• Process, interpret, and report data for proteomics and biotherapeutic characterisation projects.
• Apply and optimise MAM strategies for detailed characterisation of biologics.
• Analyse host cell protein profiles for quality and process control.
• Collaborate with software developers to streamline data processing and integration.
• Engage with industry stakeholders to translate findings into real-world applications.
• Contribute to manuscript preparation, reports, and scientific presentations.

Preferred qualifications:

• PhD in Analytical Chemistry, Biochemistry, or a related field.
• Demonstrated expertise in LC-HRMS, particularly with Orbitrap mass spectrometers.
• Experience with proteomics workflows, including digestion, enrichment, and quantification techniques.
• Expertise with Genedata Expressionist or similar proteomics data analysis platforms; knowledge of MAM workflows and HCP analysis will be considered a valuable asset.
• Knowledge of protein structure, post-translational modifications, and therapeutic protein analysis.
• Experience with bioinformatics and/or coding in R, Python, or similar languages is a plus.
• Strong organisational, communication, and collaborative skills.
• Proficiency in spoken and written English is required.

What we offer:

• Stimulating research with a dynamic and innovative research team tackling real-world challenges in biopharmaceutical development.
• Collaboration with leading scientists, engineers, and industry experts.
• Access to state-of-the-art mass spectrometry instrumentation and computational tools.

Employment:

Place of Work:

Starting date:

Contract duration:

Kontakt

• HES-SO Valais-Wallis

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